1. Plasma cells are derived from:
1) lymphocytes T.
2) lymphocytes B.
3) monocytes.
4) macrophages .
5) polymorphonuclear leukocytes.
2. The lymphocytes immature B:
1) synthesize only mu chains.
2) are progenitors of lymphocytes T and B.
3) express IgM and IgD on its surface.
4) are in a state of development so that contact with antigen can lead to tolerance.
5) should go to the thymus to mature.
3. The blood of the human newborn:
1) contains IgM, IgG and IgA.
2) contains no IgG.
3) does not contain complement components.
4) contains only IgM isotype antibody.
5) contains only maternal IgG.
4. In the process of differentiation and maturation of lymphocytes B, pre-B cells are characterized by:
1) does not express class II molecules of major histocompatibility complex.
2) express surface IgM.
3) expressing only mu chains in the cytoplasm.
4) express IgD.
5) express only light chain antibodies.
5. Plasma cells that synthesize antibodies, derived from:
1) macrophages .
2) polymorphonuclear leukocytes.
3) lymphocytes B.
4) lymphocytes T.
5) megakaryocytes.
6. In the process of differentiation and maturation of lymphocytes B, pre-B cells are characterized by state:
1) surface light chains of immunoglobulins .
2) light chains in the cytoplasm.
3) Surface IgM.
4) mu chains in the cytoplasm.
5) gamma chains.
7. During the ontogeny, complement components can already be detected:
1) after the occurrence of circulating IgA.
2) after endogenous synthesis of IgG.
3) after endogenous synthesis of IgM.
4) once it has been catabolized all maternal IgG.
5) before the endogenous synthesis of IgM.
8. A B cell can simultaneously express surface immunoglobulin :
1) different antigenic specificities.
2) of different isotype.
3) with different allotypic markers for the same locus.
4) with lambda and kappa chains.
5) None of the above.
9. During the differentiation of B cells , the first chains of immunoglobulins that are expressed are:
1) lambda chains.
2) kappa chains.
3) gamma chains.
4) mu chains.
5) delta chains.
10. The development of immunological tolerance to "self" (self-tolerance) is due to:
1) clonal deletion mechanisms.
2) T cells specific helper.
3) T cells specific suppressor.
4) T cells specific helper T cells specific suppressor.
5) a) and 3) are true.
11. Which of the following molecules do not belong to the superfamily of the immunoglobulins ?:
1) TCR.
2) CD4.
3) invariant chains.
4) CD8.
5) HLA-II.
12. The immunoglobulins integral membrane dominant in peripheral blood B lymphocytes are:
1) IgG and IgD.
2) IgA and IgE.
3) IgM and IgD.
4) IgG2 and IgM.
5) None of the above.
13. The lymphocyte B, once activated, lead to:
1) plasma cells.
2) mast cells.
3) lymphocytes C.
4) lymphocytes NK .
5) none of the above.
14. Enter the differentiation marker that identifies all cells mature T:
1) CD1.
2) CD2.
3), CD3.
4) CD4.
5) CD5.
15. The lymphocytes T and B appear for the first time in phylogeny:
1) amphibians.
2) annelids.
3) reptiles.
4) birds.
5) none of the above.
16. Indicate which of the following statements is false:
1) the lymphocytes are T in men before the sixth month of gestation.
2) cells derived from T cells "stem."
3) antigenic stimulation of macrophages in the thymus results in their differentiation into lymphocytes T.
4) pre-B cells express cytoplasmic m chains, prior to the expression of surface IgM.
5) is equivalent to tissue mast cells of the blood basophil.
17. T3 glycoprotein of lymphocytes humans makes its appearance during ontogeny through:
1) fetal liver.
2) bone marrow.
3) early intrathymic stage.
4) late intrathymic stage.
5) lymph nodes.
18. The order of appearance of surface markers in the ontogeny of lymphocytes B mouse is:
1) Sigma, Fc receptor, Ia antigens, Sigdo, Complement Receptor.
2) Ia antigens, Fc receptor, sigma, Sigdo, Complement Receptor.
3) Sigdo, Complement receptor, Ia antigens, sigma, Fc receptor.
4) Complement receptor, Ia antigens, Fc receptor, sigma, Sigdo.
5) none of the above.
19. What level phylogenetic appears a second class of immunoglobulin other than IgM? :
1) ciclóstomos and elasmobranchs.
2) teleosts.
3) amphibians.
4) birds.
5) mammals.
20. In humans, the postnatal period, the body which differentiate lymphocytes from B lymphoid precursor cells is:
1) scam.
2) spleen.
3) liver.
4) associated lymphoid tissue gastrointestinal tract.
5) bone marrow.
21. Concerning the development of lymphocytes B, point to the FALSE statement.
1) a lymphoid progenitor cell gives rise to a pre-B lymphocytes, characterized by the presence of cytoplasmic IgM.
2) thereafter, the cells express very immature B IgM on their cell surface HLA-II also (DR) and the fraction FcIgG receiver.
3) starts the phase dependent antigen when the mature B cell, expressing together IgM, IgD, R. Rc FcIgG and C3 on the surface, change its production of Ig gene to a particular class that expresses surface-associated IgD.
4) activated by specific antigen, which is exposed in a secondary lymphoid organ, the immature B cell differentiates into plasma cell production of antibodies or lymphocytes B of memory.
5) plasma cells do not express surface IgD.
22. Regarding the development of T lymphocyte, point to the FALSE statement.
1) differs from other lymphoid cells in establishing a pool or reserve of T cell intrathymic the beginning of life maintained by a proper recirculation.
2) accounts for 70-80% of lymphocytes in peripheral blood.
3) the first strain identified in the thymus are lymphocyte pro-T with CD7 that subsequently begin the synthesis of CD3, CD2 (rec. LFA-3) and TCR (receptor for Ag on the T cell).
4) lymphocytes expressing T TCR alpha / beta or gamma / delta.
5) the majority of lymphocytes in the peripheral blood were TCR gamma / delta (tcr1).
23. What stage of maturation of lymphocytes T CD4 and CD8 are positive?
1) cell prot.
2) lymphocyte pret.
3) immature T cells.
4) mature lymphocyte.
5) can never be associated.
24. In connection with the immune response, point to the FALSE statement.
1) always requires a preliminary recognition of antigenic determinants or epitopes of antigens.
2) recognition determines the specificity of the immune system.
3) each cell has about 100,000 B Rc for the antigen on its surface, surface Ig, with identical variable region and specificity.
4) lymphocytes B. like the T, only recognize antigens on the surface of antigen presenting cells.
5) the deletion or clonal anergy (Burnett) is to eliminate those cells whose receptors have T epitope specificity similar to self antigens.
25. Which of the following is NOT part of the Ig superfamily?
1) IgG.
2) TCR.
3) CD 4.
4) CD 3.
5) LFA-1.
26. Induced immune tolerance can be described as:
1)-specific epitope of a particular antigen.
2) more easily inducible in adult animals.
3) a synonym for self-tolerance.
4) increased with the use of adjuvants.
5) lockable by cyclophosphamide.
27. Immune tolerance is defined as:
1) lack of response to all types of transplants.
2) lack of plasma cells.
3) the lack of response to any foreign antigen and against self antigens.
4) due to the action of T cells cytotoxic.
5) lack of secondary response against a Ag
28. With regard to the ontogeny of lymphocytes in the thymus T is false that:
1) the CD7 molecule precedes the appearance of the marker CD2 and defines the population of pro-T.
2) the stage of pre-T cells is characterized by the expression of CD2 in the absence of CD4 and CD8 Ag.
3) the gene rearrangement of T Cell Rc begins in the pre-T stage.
4) cells doubly positive CD4 and CD8 are an immature population that has no significant expression in peripheral blood.
5) the synthesis of proteins for the two types of T Cell Rc occurs simultaneously with the chains of the CD3 complex that is associated with them.
29. Point out the wrong answer. During the maturation of lymphocytes B:
1) CD19 and CD20 Ag is expressed throughout ripening.
2) the CD23 molecule is expressed only in the final stages of differentiation.
3) the cells mature and immature B have a strong expression of HLA-II molecules on their surface.
4) the Ag CD10 (CALLA) is not exclusive to lymphocytes B.
5) the cells do not express B Rc for the cytokines IL-1, IL-2 and IL-4.
30. In the ontogeny of a B cell are in first place strings:
1) kappa light.
2) lambda light.
3) heavy delta.
4) invariant.
5) mu heavy.
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